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Monday, March 28, 2011

New-Onset Diabetes With Statins

UPDATE: 12 January 2012

Another report is out today linking statin drugs and diabetes. Natural Health News has been reporting on statins since 2006 and we have been covering the drugs in our other venues since 1996.

Numerous articles on this topic can be located on Natural Health News using our search function on the main page.

Here is a related report

30 March 2011 - 
People with Diabetes (PWD) are 70% more likely to have liver disease. 
Diabetes Diary: This is now in process of publication, pre publication copies are $8, available from us. 
Diabetes increases Parkinson's risk
I hope you are connecting the dots...

28 March -
Need I say more?  Now more studies shoe increased risk of diabetes among other health problems from statins.  And the cookie cutter medicine machine wants YOU to take this drug if you have diabetes.  Its doing the same as aspartame.  Red Yeast Rice  is a statin and will have this effect in some people.

We offer a very good supplement to help raise HDL, lower LDL and reduce total cholesterol while decreasing triglycerides. 


Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin

Results From 3 Large Randomized Clinical Trials

David D. Waters, MD, Jennifer E. Ho, MD,David A. DeMicco, DPharm, Andrei Breazna, PhD, Benoit J. Arsenault, PhD, Chuan-Chuan Wun, PhD,John J. Kastelein, MD, PhD, Helen Colhoun, MD, PhD and Philip Barter, MD, PhD Division of Cardiology, San Francisco General Hospital, and the University of California at San Francisco, San Francisco, California
 Pfizer, Inc., New York, New York
 Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
 Department of Public Health, University of Dundee, Dundee, Scotland
Heart Research Institute, Sydney, Australia
Manuscript received July 28, 2010; revised manuscript received October 4, 2010, accepted October 11, 2010.
* Reprint requests and correspondence: Dr. David D. Waters, Division of Cardiology, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, California 94114 (
Objectives: We sought to examine the incidence and clinical predictors of new-onset type 2 diabetes mellitus (T2DM) within 3 large randomized trials with atorvastatin.
Background: Statin therapy might modestly increase the risk of new-onset T2DM.
Methods: We used a standard definition of diabetes and excluded patients with prevalent diabetes at baseline. We identified baseline predictors of new-onset T2DM and compared the event rates inpatients with and without new-onset T2DM.
Results: In the TNT (Treating to New Targets) trial, 351 of 3,798 patients randomized to 80 mg of atorvastatin and 308 of 3,797 randomized to 10 mg developed new-onset T2DM (9.24% vs. 8.11%, adjusted hazard ratio [HR]: 1.10, 95% confidence interval [CI]: 0.94 to 1.29, p = 0.226). In the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial, 239 of 3,737 patients randomized to atorvastatin 80 mg/day and 208 of 3,724 patients randomized to simvastatin 20 mg/day developed new-onset T2DM (6.40% vs. 5.59%, adjusted HR: 1.19, 95% CI: 0.98 to 1.43, p = 0.072). In the SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) trial, new-onset T2DM developed in 166 of 1,905 patients randomized to atorvastatin 80 mg/day and in 115 of 1,898 patients in the placebo group (8.71% vs. 6.06%, adjusted HR: 1.37, 95% CI: 1.08 to 1.75, p = 0.011). In each of the 3 trials, baseline fasting blood glucose, body mass index, hypertension, and fasting triglycerides were independent predictors of new-onset T2DM. Across the 3 trials, major cardiovascular events occurred in 11.3% of patients with and 10.8% of patients without new-onset T2DM (adjusted HR: 1.02, 95% CI: 0.77 to 1.35, p = 0.69).
Conclusions: High-dose atorvastatin treatment compared with placebo in the SPARCL trial is associated with a slightly increased risk of new-onset T2DM. Baseline fasting glucose level and features of the metabolic syndrome are predictive of new-onset T2DM across the 3 trials.
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rimon said...

The potential association between statin use and new-onset diabetes gained attention in 2001 when a post hoc analysis of another primary.
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Anonymous said...

The potential association between statin use and new-onset diabetes gained attention in 2001 when a post hoc analysis of another primary.

Unknown said...

we have been following the problems with statins since the 90s. little has changed other than more are duped into taking a useless, expensive, and side effect laden drug.

GreenHealerRN,MD,FAAP,FACP said...

META ANALYSIS of 39,791 patients:
Statins can NOT be used in people with severe chrronic liver diseases, which is sad, because few interventions have ever been found to be so SAFE and EFFECTIVE.

Unknown said...

Our comments and opinion about statin drugs are responsible. They are based on the real science not PR from the Big PhRMA manufacturer. Check out the number of credible MDs and others who have been questioning these drugs and their risks for a decade or more. Do your due diligence and think before you add such inflammatory comments that are defensive and seemingly an attack to what you have been told to believe about these risky drugs. The point is that you don't need statins to properly and physiologically balance your cholesterol.