UPDATE: 11/12/09
Pomegranate’s Protection Potential Grows
The anti-prostate cancer effects of pomegranate and its extracts may be related to stopping an enzyme in the liver that processes environmental carcinogens, according to a new study.
Pomegranate, a rich source of antioxidants, has been linked to improved heart health, but a growing body of evidence indicates the fruit also protects against prostate cancer. Studies have also reported a role for pomegranate in joint health by slowing cartilage loss in arthritis.
It is the antioxidants and ellagitannin compounds like punicalagins and punicalins, which account for about half of the fruit’s antioxidant ability, that are reportedly behind the proposed health benefits.
The new study, led by Daneel Farreira from the University of Mississippi, deepens our understanding of how the constituents of the fruit may boost prostate health.
"Our results indicate a previously unexplored pathway through which pomegranate juice constituents may contribute to prostate cancer chemoprevention," they wrote.
Writing in the Journal of Agricultural and Food Chemistry, Ferreira and his co-workers reported that pomegranate’s ellagitannin compounds may inhibit the activity of cytochrome P450 1B1, an enzyme known to be highly expressed in various human cancers, but not in normal tissues, an established target in the prevention of prostate cancer.
"Our study has asserted a previously unknown mechanism of action of pomegranate juice constituents, which could potentially contribute to prostate cancer chemoprevention," they wrote. "We proved that systemically available metabolites of pomegranate juice are effective inhibitors of CYP1B1 enzyme activity/expression and could lower the incidence of prostate cancer initiation and sustenance."
The researchers performed an in vitro experiment to test the ability of pomegranate ellagitannins and its microbial metabolites to inhibit CYP1B1.
They found that the microbial metabolite urolithin A showed the greatest activity for inhibiting CYP1B1, with a 2-fold selectivity over another enzyme CYP1A1, which actually has anti-cancer activity. Inhibition of CYP1A1 is therefore not desirable.
"It is also well-known that prostate cancer typically possesses long latency periods and develops in older men; therefore, cancer chemoprevention by dietary supplement-based intervention is a desirable form of chemotherapy," wrote the researchers. "Pomegranate juice consumption, thus, may be of considerable advantage in prostate cancer chemoprevention, not only in patients with a genetic predisposition toward prostate cancer but also in patients undergoing cancer therapy."
Journal of Agricultural and Food Chemistry
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Contributed by friends:
Phytonutrients: the Biochemistry of how the Healthiest Foods Prevent Cancer
There are many nutraceuticals that have both cancer preventive and cancer suppressive properties. You will not hear about them if you do not go out of your way to review the scientific literature, or have access to those that do so. Pharmaceutical companies are sitting on many natural substances that they know can treat any number of diseases, but you will not hear about them unless they can tweak the molecules enough to get a patent and still retain some of the healing properties. Their job is not to let you in on what they know. Their job is to make money. Mr. Fox reviews some of these readily available natural compounds and extracts. The list is actually quiet long, but his review will give you a place to start
Stephen Fox and KP Stoller, MD President, International Hyperbaric Medical Assoc Medical Director,
Hyperbaric Medical Center of New Mexico
Currently, the terms "phytonutrient" and "phytochemical" are being used interchangeably to describe those plant compounds which are thought to have health-protecting qualities. The antioxidant, immune boosting and other health promoting properties of active compounds in plants are being investigated.
However, in common usage, they have a more limited definition. They are usually used to refer to compounds found in plants that are not required for normal functioning of the body but that nonetheless have a beneficial effect on health or an active role in the amelioration of disease. Thus, they differ from what are traditionally termed nutrients in that they are not a necessity for normal metabolism, and their absence will not result in a deficiency disease. What is beyond dispute is that phytonutrients have many and various beneficial health effects. For example, they may promote the function of the immune system, act directly against bacteria and viruses, reduce inflammation, and may also be associated with the treatment and/or prevention of cancer (the focus of this article), cardiovascular disease and any other malady affecting the health or well-being of an individual.
Allyl Sulfides are found in garlic, onions, and shallots. They suppress growth of tumor cells and bring about apoptosis, or natural cell death (cancer cells find ways to stop this process); allyl sulfides also promote excretion of cancer causing chemicals. They lessen stomach and colon cancer, and help to treat colds, blood circulation, inflammations, arteriosclerosis and diabetes.
Quercetin is a flavonoid found in medicinal plants which works to prevent inflammations and inhibits the release of histamines. In a recent study in the British Journal of Cancer, quercetin and ultrasound were used to treat skin and prostate cancers, with a 90% death of the cancer cells within 48 hours, and no visible deaths of the normal cells! This phytonutrient is used to treat cancer, prostatitis, heart disease, cataracts, and respiratory diseases like bronchitis and asthma. It is found in capers, apples, tea, onions, grapes, citrus, broccoli, leafy green vegetables, cherries, turmeric, and cranberries.
Limonene is a hydrocarbon, taking its name from lemons, and is found in lemons and in noni. It helps the liver clear carcinogens from the body and promotes cell differentiation.
Lutein (from Latin “Lutea” meaning yellow) is one of 600 known carotenoids. Found in leafies like spinach and kale, it is used as an antioxidant. It is also found in mango and winter squash. Early studies have shown high intakes reduced risk of breast, colon, endometrial (uterine) and prostate cancers. It is found in concentrated areas of the macula, the small area of the retina responsible for central vision.
Catechin is found primarily in green tea and is an anti-oxidant that helps keep tumors from taking hold and growing (herbalYODA's note: organic cocoa also is good but we advise limiting green tea bacuse of its effect on the pancreas). According to Norman Hollenberg, Professor at Harvard Medical School, epicatechin, a metabolic form of catechin, can reduce the risk of all four of these major human health problems: stroke, heart failure, cancer, and diabetes. His studies were based on the Kuna people in Panama who drink up to 40 cups of cocoa a week, with only 10% being struck by the big four diseases!
Chlorophyll is the prime biochemical for all respiration and life in the plant world. It is strikingly similar in form to hemoglobin, differing primarily in that chlorophyll has magnesium in the center and hemoglobin has iron. This would explain partly why wheat grass juice is so instantly beneficial for those with “tired blood” and anemia. It is found in spirulina, chlorella, barley grass, and in leafy greens. It is a potent detoxification agent and protects genes against the biochemical damage that leads to cancer cell development.
Sulphoraphane is the phytonutrient that activates enzymes that detoxify carcinogens; it interferes with cancer cell growth and promotes cancer cell death. It is found in broccoli, and especially in broccoli sprouts.
Lycopene is best known for providing protection against prostate cancer, and may also help defend the physiochemistry of humans against lunch and stomach cancer malignancies. It is found in tomatoes, watermelon, pink grapefruit, guava, papaya, and in rosehips. It is the most powerful quencher of singlet oxygen, 100 times more so than Vitamin E. It is helpful for cardiovascular disease, cancer, diabetes, osteoporosis, and male infertility. Recently the United States Food and Drug Administration concluded that tomatoes reduce no risk for lung, colorectal, breast, or cervical cancer, and only limited evidence for reduced risk of prostate, ovarian, and pancreatic cancers, all derived from 145 studies after a coalition of tomato growers and tomato product producers asked to list anti cancer benefits in nutritional labels on their products. We rarely agree with the FDA, so keep eating lots of tomatoes for their carcinogenic properties, which the FDA may or may not ever get around to formally endorsing….
Ellagic acid appears to defend cells lining the digestive tract against carcinogenic substances, and has prevented colon and esophageal cancer in animals. It is found in pomegranates, grapes, raspberries, and strawberries. Apparently, it also may help the liver to break down and remove cancer causing substances from the blood. One study in Clinical Nutrition in 2004 showed clearing of plaque in the carotid artery after three years of pomegranate juice as a supplement. Italian researchers have also found ellagic acid reducing the side effects of chemotherapy in advanced prostate cancer treatment in men, and the Hollings Cancer Institute at the University of South Carolina conducted a double blind study on 500 cervical cancer patients that showed ellagic acid caused G-arrest within 48 hours and apoptosis within 72 hours, for breast, pancreas, esophageal, skin, colon, and prostate cancers. Researchers speculate that this results when ellagic acid forms adduct (from Latin, “drawn toward”) with DNA, thus masking binding sites to be occupied by the carcinogens.
Resveratrol causes apoptosis or cancer cell death. Resveratrol is a phytoalexin and is sold as a nutritional supplement. A number of beneficial health effects, such as anti-cancer, antiviral, neuroprotective, anti-aging, anti-inflammatory and life-prolonging effects have been reported, although these studies used animal subjects. Resveratrol is found in the skin of red grapes and as a constituent of red wine. David Sinclair of the Harvard Medical School and cofounder of Sirtris Pharmaceuticals has found that resveratrol increases the activity of a protein called SIRT1. Resveratrol significantly increases the lifespan of yeast and mice. Resveratrol is produced by several plants, apparently due to its antifungal properties. It is found in widely varying amounts in grapes (primarily the skins), raspberries, mulberries, in peanuts, berries of Vaccinium species, including blueberries, bilberries, and cranberries. In grapes, resveratrol is found primarily in the skin and seeds. This is particularly true for Muscatine grapes, whose skin and seeds have about 100 times the concentration as the pulp. Resveratrol interferes with all three stages of carcinogenesis - initiation, promotion and progression.
Experiments in cell cultures of varied types and isolated subcellular systems in vitro imply many mechanisms in the pharmacological activity of resveratrol, and it was reported effective against neuronal cell dysfunction and cell death and in theory could help against diseases such as Huntington's disease and Alzheimer's disease. Again, has not yet been tested in humans for any disease. Research at the Northeastern Ohio Universities College of Medicine and Ohio State University indicates that resveratrol has direct inhibitory action on cardiac fibroblasts and may inhibit the progression of cardiac fibrosis. In some lineages of cancer cell culture, resveratrol has been shown to induce apoptosis, which means it kills cells and may kill cancer cells. Resveratrol is under extensive investigation as a cancer chemopreventive agent. The Chemoprevention Database reports six studies showing that small doses of dietary resveratrol can reduce colon carcinogenesis in rats and mice. This biochemical has also shown great promise in longevity studies and in improving athletic performance of all kinds.
Anthocyanins are antioxidants that protect DNA against cancer causing damage and promote apoptosis, as well as the ability to keep cancer cells from spreading. It is found in berries, grapes, black currants, acai, mangosteen, and goji. They also act as “sunscreens” protecting cells by absorbing blue green light, thereby protecting tissues from photoinhibition or high light stress. Some researchers maintain that the red coloration of leaves may camouflage leaves from herbivores. These properties continue even after consumption by other organisms. In December 2004 a study at Michigan State University noted that anthocyanin could boost insulin production by up to 50%, and a 2007 study at the University of Pittsburgh showed that it killed human cancer cells while not affecting healthy cells, even with leukemia and lymphoma, within 18 hours. The biochemical mechanism is that the anthocyanins caused the normal cells to release peroxides which killed the cancer cells. Dr. Xiao Ming Yin, Associate professor of pathology at University of Pittsburg School of Medicine stated that “the hope is that black raspberries and other botanicals might provide doctors with less toxic alternatives to drug and radiation therapies.”
Please note that we are able to supply you with high quality, and mostly organic antioxidant products as mentioned in this article. NHN readers receive a discount and we offer international shipping to readers outside the US
