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Showing posts with label folic acid. Show all posts
Showing posts with label folic acid. Show all posts

Tuesday, October 11, 2011

VITAMINS HAVE NEVER KILLED ANYONE

I am sure everyone is buzzing about the fallacious news stories from the last couple of days that are telling you taking vitamins is risky for your health.  Every time I hear reports on these studies I get mad.  I get more so when I hear the local ABC outlet news anchor say she does fair and balanced reporting.
If her reporting was fair and balanced she would include the following information from Mitch Stargrove an ND I have known over some years:
It is not advisable to make a causal statement of excess risk based on these observational data..." Without proper accounting of and informed choices for form, dose, combination, sequencing of nutrients this data says little of clinical consequence. Moreover, the fundamental premise of natural medicine is personalized and evolving care in concert with a healthcare professional trained and experienced in nutritional therapies. All contemplated supplement usage should be discussed with primary care providers, such as (licensed) naturopathic physicians, who are trained in their appropriate, prudent and proper usage. Lastly, reliance of foods, i.e., fruits and vegetables, is not what it used to be. Solid research shows that the nutrient content of commercially grown foods sold in the USA has declined markedly over the past 30 years; presumably due to industrial/petrochemical agribusiness practices and priorities. Other problematic factors have been mentioned by previous responses to this alarmist declaration which reveals a hostile and prejudiced posture in the conventional medical world that does not serve the patient's best interests nor the methodology of science and discovery.


The only concern I have fore vitamins used by people over 40 is iron unless the person is clearly anemic.  Iron is known to be a higher risk of heart attack in this age group.


Zinc is important for immune support and endocrine health.  If elevated Copper is usually low.  Too much copper is a risk but reputable supplements know the safe limits.


Magnesium is good for the brain and nervous system just like the B vitamins.  Magnesium is usually deficient especially if you are using Rx drugs. 


Many forms of calcium are not well absorbed and yet this "study" tells you to take it.


If you need help deciding on your supplements we offer this service through our Health Forensics programs. Email us for more information.


I'll continue taking my vitamins, Thank you!


From Natural Products Insider


Then consider this from MedPage Today


Readers Say Vitamin Levels Should Be Checked Yearly

By Chris Kaiser

Cardiology Editor, MedPage Today
Published: October 07, 2011
Processed foods, mineral-depleted soil, overcooked vegetables, increased stress levels -- all of these increase the chances of having a vitamin deficiency, according to a vocal majority ofMedPage Today readers who commented on last week's poll.
We asked readers if and when patients should be assessed for vitamin deficiencies. Of the more than 2,200 votes, 69% said that patients' vitamin levels should be assessed at least annually.
"I cannot remember how many patients have been rescued from dementia and psychosis by B12, especially when I have a geriatric focus," said one doctor, who also touted vitamin D, calcium, fish oil, and thyroid testing. "Everybody deserves a look about once a year."
But once a year was not enough for some (9% said every visit) and too much for others. One cardiologist said he or she tests vitamin levels every six months with a "pick up rate over 25%." Another commenter said that yearly testing seems too frequent. "Getting a baseline every five years with additional testing as needed seems better."
We received several anecdotal accounts about vitamin deficiency being caught, but only when the patient requested the test.
"I was diagnosed with severe insufficiency of vitamin D and only had it tested because I requested it," said one woman, who added that her mother and daughter were subsequently found to be vitamin D-deficient.
"I have just been rescued from severely low vitamin D levels, and my daughter has been found to have low vitamin levels as well. I wish my doctors had been checking levels all along," noted another MedPage Today reader.
And another expressed similar exasperation. "It was not until I was diagnosed with osteoporosis that I had a vitamin D 25-OH test, and found out that despite being outside every day, my level was insufficient. By then it was too late. I am very disappointed that my physician did not order this inexpensive test years ago. Now, I have asked for a B12 test as well."
One woman's B12 deficiency mimicked multiple sclerosis and she went through a battery of tests before a neurologist ordered vitamin testing for her.
"It baffles me that insurance companies aren't pushing for annual vitamin testing, because so many conditions can be resolved with proper vitamin supplementation," wrote one woman, who also was found deficient in vitamin D after she requested the test.
The comments also parsed the meaning of "recommended daily allowance" (RDA). Most agreed that the RDA is not meant to prevent disease states but more to support optimum health.
"The original purpose of RDAs was to specify the amounts of various micronutrients needed by the 'average' person to guard against deficiency disease; the fact that a person does not have scurvy or anemia doesn't mean she/he is getting enough vitamin C or B12, respectively, to be as healthy as possible," wrote one commenter.
But what is the root cause of vitamin deficiency? "We need to start with nutrition," was how one physician simply put it.
Others, as well, chimed in with the notion that vitamin deficiencies and chronic diseases are symptoms of malnourishment, which is symptomatic of poor eating habits.
As expressed by one European, "Ultimately, there is simply no substitute for a healthy diet. Sadly, American diets often lean toward processed foods, which tend to be low in nearly every (micro)nutrient other than sodium."
"Healthy eating is almost nonexistent today," said another commenter. "Processed and modified foods simply are not as nutrient-dense as their counterparts were perhaps 20 years ago."
And, as usual, we had at least one post worthy of going in the X-file.
"I wonder how much this 'concern' is being driven by yet more EU 'directives' banning the sale of 'natural' additives and supplements," this commenter wrote. "Whilst the profession should remain wary of too close an 'association' with what is considered as 'Big Pharma,' we should also remain acutely aware of signs and symptoms of deficiencies which have been known and recognized for centuries. The prescribing decisions must always be made as a result of knowledge, not some bureaucratic nonsense from an invisible and unaccountable back-room mandarin with several bees in his bonnet and 'fees' to be earned!"

And now the meaningless study -


Dec 27, 2009
NEW YORK (Reuters Health) – An analysis of "real-world" clinical data indicates that vitamin E, and drugs that reduce generalized inflammation, may slow the decline of mental and physical abilities in people with Alzheimer's ...

Dietary Supplements Linked to Higher Death Risk

By Todd Neale, Senior Staff Writer, MedPage Today
Published: October 10, 2011
Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner
In postmenopausal women, the use of several common vitamin and mineral supplements was associated with an increased risk of death, researchers found.

After adjustment for multiple potential confounders, use of multivitamins and vitamin B6, folic acid, iron, magnesium, zinc, and copper supplements was associated with greater all-cause mortality through 19 years of follow-up (HRs 1.06 to 1.45), according to Jaakko Mursu, PhD, of the University of Eastern Finland in Kuopio, and colleagues.

Use of a daily calcium supplement, on the other hand, was associated with a lower risk of death (HR 0.91, 95% CI 0.88 to 0.94), the team reported in the Oct. 10 issue of the Archives of Internal Medicine.


"Based on existing evidence, we see little justification for the general and widespread use of dietary supplements," they wrote, citing a body of literature generally supporting no association with mortality, with some suggestions of harm. "We recommend that they be used with strong medically based cause, such as symptomatic nutrient deficiency disease."
"We cannot recommend the use of vitamin and mineral supplements as a preventive measure, at least not in a well-nourished population," they wrote. "Those supplements do not replace or add to the benefits of eating fruits and vegetables and may cause unwanted health consequences."
Taking dietary supplements to improve health and prevent diseases is widespread, with about half of U.S. adults using one or more in 2000, according to Mursu and colleagues. Annual sales top $20 billion.
The long-term impact of supplementation is unknown, however, and some studies have suggested a relationship between supplements and increased mortality.
As Rita Redberg, MD, of the University of California San Francisco, wrote in an editor's note, "manufacturers are not required to disclose to the FDA or to consumers the evidence they have regarding their products' safety, nor must they empirically back up claims of purported benefits."
In light of this uncertainty, Mursu and colleagues examined the use of vitamin and mineral supplements among 38,772 postmenopausal women participating in the Iowa Women's Health Study. The mean age of the women at baseline in 1986 was 61.6.
The participants reported their use of supplements in 1986, 1997, and 2004. The percentage who reported using at least one supplement daily increased from 62.7% to 85.1% during the study. In 2004, more than one-quarter of the women (27%) said they used four or more.
The most commonly used supplements were calcium, multivitamins, vitamin C, and vitamin E.
Through 2008, 40.2% of the women died.
After adjustment for demographics, dietary and lifestyle factors, comorbidities, and use of hormone replacement therapy, the following supplements were associated with a greater risk of death during follow-up:
  • Multivitamins: HR 1.06 (95% CI 1.02 to 1.10)
  • Magnesium: HR 1.08 (95% CI 1.01 to 1.15)
  • Zinc: HR 1.08 (95% CI 1.01 to 1.15)
  • Iron: HR 1.10 (95% CI 1.03 to 1.17)
  • Vitamin B6: HR 1.10 (95% CI 1.01 to 1.21)
  • Folic acid: HR 1.15 (95% CI 1.00 to 1.32)
  • Copper: HR 1.45 (95% CI 1.20 to 1.75)
Absolute increases in risk ranged from 2.4% with multivitamins to 18% with copper.
After multivariate adjustment, use of calcium supplementation was associated with a lower risk of death (HR 0.91, 95% CI 0.88 to 0.94). The absolute risk reduction was 3.8%.
To account for the multiple comparisons made, however, the researchers set a P value of less than 0.003 to establish significance. Only the increase associated with multivitamins, calcium, and copper remained significant using this threshold.
"However, many of the additional statistical tests were confirmatory, strengthening confidence that findings were not explainable by chance," Mursu and colleagues noted.
In particular, the findings related to iron and calcium remained consistent when the analysis was restricted to follow-up from 1986 to 1996, from 1997 to 2003, and from 2004 to 2008.
In addition, the mortality risk associated with iron supplementation increased in a dose-response fashion.
The relationship was not significant for doses of 200 mg/day or less, but was significant for a dose of 201 to 400 mg/day (HR 1.35) and for a dose of 400 mg/day or more (HR 1.57).
"Iron is suggested to catalyze reactions that produce oxidants and thus promote oxidative stress," the authors noted, acknowledging that they did not examine possible mechanisms in the current study.
"However, we cannot rule out the possibility that the increase in total mortality rate was caused by illnesses for which use of iron supplements is indicated," they wrote. "Chronic disease, major injury, and/or operations may cause anemia, which is then treated with supplemental iron. However, we could find no evidence for such reverse causality."
In their commentary, Bjelakovic and Gluud said that "one should consider the likely U-shaped relationship between micronutrient status and health," with risks associated with both insufficient and excessive intake.
"Therefore, we believe that politicians and regulatory authorities should wake up to their responsibility to allow only safe products on the market," they wrote.
Added Redberg, "A better investment in health would be eating more fruits and vegetables, among other activities. Because commonly used vitamin and mineral supplements have no known benefit on mortality rate and have been shown to confer risk, this article has been given our 'Less Is More' designation."
Mursu and colleagues noted that their study was limited by the possibility of residual confounding and changes in supplement use during the study, the inability to exclude the chance that some supplements were taken in response to symptoms or clinical disease, the lack of data on nutritional status or detailed information on the supplements used, and the study sample comprised of white women, which limits the generalizability of the findings.
The study was partially supported by grants from the National Cancer Institute and the Academy of Finland, by the Finnish Cultural Foundation, and by the Fulbright program's Research Grant for a Junior Scholar.
One of Mursu's co-authors is an unpaid member of the scientific advisory board of the California Walnut Commission.
Bjelakovic and Gluud reported that they had no conflicts of interest.

Oct 13, 2008
More Vitamins Please. In the long ago days of the youth of my children our pediatrician rather naturally had us offer liquid vitamin drops daily from infancy onward. Back then it was common to find 400 to 800 IU 0f ...
May 25, 2010
Good News About Vitamins. That TV Doctor Lisa Masterson would just love you to believe her propaganda force fed to medical students and reinforced by mainstream media that all you need for good nutrition is a healthy ...
Jul 03, 2008
Fatty meals may cloud the brains of people with type 2 diabetes, but antioxidant vitamins can help clear the fog, Canadian researchers demonstrated in a study they conducted. The findings suggest, the researchers say, ...



Thursday, September 09, 2010

B Vitamins for a Healthy Baby

Vitamin 'may help prevent' spina bifida is an article in today's BBC News.

In the late 60s when I was in college for my second bachelor's degree (nursing) I learned in my nutrition studies that B vitamins would prevent Spina Bifida.

In the early 90s when I met Herr Kufner, I talked with him about RKBio Blend and how its rich supply of B vitamins helped prevent Spina Bifida.

These articles are from Natural Health News -

Why it pays to rely on nutritional supplementation

and

http://naturalhealthnews.blogspot.com/2009/03/mainstream-medicine-slow-to-catch-on.html

And now some some 40 years after I learned about B vitamins to prevent Spina Bifida, the BBC reports it may help be a preventive.

Whose merry-go-round are we on?

Monday, January 11, 2010

Alzheimer's Reminder, Don't Overlook These Causes

Neurological Impact Of Fluoride Toxicity, from an article I wrote in 2001 and other important information to consider, plus the impact of overusing Serotonergic Drugs

While the links from fluoride consumption to cancer, osteoporosis, and other physical ailments are long established, recently studies have shown that fluoride impact is much broader and includes neurological and cerebrovascular effects.

Fluoride has been banned in Sweden, Norway, Denmark, West Germany (now unified), Italy, Belgium, Austria, France, and The Netherlands.

Tea (not including the herbal varieties) is a surprising culprit, in addition to fluoridated drinking water supplies and fluoride toothpaste.

A 52-week study of the factors that enhance or inhibit the bioavailability of aluminum and its effects on the nervous system was published in 1998 in the Journal of Brain Research. According to the report, the equivalent of fluoridated drinking water in terms of elemental fluorine levels had an impact on brain tissue similar to the pathological changes found in humans with Alzheimer's and other forms of dementia.
The introduction to the report noted, "One of their most remarkable findings was that animals administered the lowest dose of aluminum-fluoride (0.5 ppm) exhibited a greater susceptibility to illness and a higher incidence of mortality than the animals administered the higher levels (5 ppm, 50 ppm) of aluminum [without the fluoride].

"While the small amount of aluminum-fluoride in the drinking water of rats required for neurotoxic effects is surprising, perhaps even more surprising are the neurological results of the sodium-fluoride at the dose given in the present study (2.1 ppm) [the amount used to achieve 1 ppm of elemental fluorine used in fluoridation].

"In most reports of chronic fluoride toxicity, the data provided are usually limited to weight loss, dental and skeletal changes, indicators of carcinogenesis, and damage to soft tissues.

"Fluoride has diverse actions on a variety of cellular and physiological functions, including the inhibition of a variety of enzymes, a corrosive action in acid mediums, hypocalcemia [low blood calcium], hyperkalemia [excess blood potassium], and possibly cerebral impairment."

The authors summarize, "Chronic administration of aluminum-fluoride and sodium-fluoride in the drinking water of rats resulted in distinct morphological alterations of the brain, including the effects on neurons and cerebrovasculature."

A previous study by Mullenix, et al. in Neurotoxicology and Teratology, 1995, documents abnormal behavioral responses by animals exposed to fluoride at various stages of gestation, which resulted in permanent hyperactivity if exposed prenatally, or extreme lethargy if exposed after birth, with some animals not able to find their way out of a circular maze to the same food source every day.

This study of the neurological effects of sodium fluoride, which is commonly touted as a safe and even health-promoting drinking water additive, came on the heels of a recent report in the Journal of the American Medical Association that 2 million people a year become ill, and more than 100,000 die, from medicines judged by the medical community to have been "correctly prescribed and correctly administered."

The fluoride/aluminum association is of particular importance as it relates to Alzheimer's Disease. Aluminum by itself is not readily absorbed by the body. However, fluoride ions combine with aluminum to form aluminum fluoride, which is absorbed by the body. In the body, the aluminum eventually combines with oxygen to form aluminum oxide or alumina. Protein bound to alumina in afflicted brains forms the plaques and tangles characteristic of Alzheimer's disease.

In a study by Dr. Robert Isaacson at the State University of New York, aluminum fluoride was added to rats' diet. This, contrary to normal expectations, passed through the brain barrier and gave the rats short-term memory loss, smell sensory loss, unsteady gait, and loss of structures of the neo-cortex and hippocampus, all symptoms of Alzheimer's. A Varner and Jensen study conducted with Isaacson confirmed this in 1998.
B-12 AND FOLATE CAN REDUCE ALZHEIMERS RISK  Elderly people with low blood levels of vitamin B-12 and folic acid (folate) may face an increased risk of developing Alzheimer's disease. Vitamin B-12 plays an important role in maintaining nerve cells, and some research has linked low blood levels of the vitamin to Alzheimer's and mental decline. Few studies have looked at whether there is such a connection between Alzheimer's and folate, a B vitamin key to the production and maintenance of body cells.

The May 8, 2001, issue of Neurology reports on a study of 370 individuals aged 75 and older, in which investigators found that those with low levels of either vitamin were twice as susceptible to Alzheimer's over a 3-year period as those with normal levels. The link was even stronger among study participants who performed well on mental tests at the start of the study.
The reason for the link is unclear, but low blood levels of B-12 and folate can lead to elevations in the amino acid homocysteine, which may in turn damage nerve cells, the authors note. Vitamin B-12 is found in meat, fish, eggs, and milk. Vegetarians are advised to supplement their B-12 intake. Folate occurs naturally in leafy green vegetables, dried beans and peas, and citrus fruits, among others. Many cereals are fortified with folic acid, the synthetic form of folate.

Alzheimer's is the most common form of dementia, affecting an estimated 4 million Americans. The exact cause remains elusive, but scientists believe genetics and environmental factors conspire to trigger the onset of the disease.

The May 8, 2001 issue of Neurology Magazine listed the following as warning signs of Alzheimer's Disease: memory loss that affects job skills; language problems; difficulty performing familiar tasks; misplacing objects; changes in mood and behavior; poor judgment; disorientation as to time and place; personality changes; problems with abstract thinking; and loss of initiative.

Brain imaging is recommended to help rule out other causes of memory loss or dementia. This includes computed tomography (CT) and magnetic resonance imaging (MRI). Genetic testing has not been found particularly useful. [Annual Meeting of the American Academy of Neurology, 2001]

The elderly are not the only ones that need to worry about B-12. According to one practitioner, the most common cause of B-12 deficiency is a vegetarian diet.

The drug Prilosec (omeprazole) has been shown to decrease B-12 absorption [Annual of Pharmacotherapy, May 1999]. This is possibly due to its effects on decreasing the production of intrinsic factor, which is needed for proper B-12 absorption. Other medications may have similar adverse effects.

There is also little question now that B-12 and folic acid are useful to reduce homocysteine and the associated increase in heart disease and birth defects.

Thursday, December 11, 2008

I Must Be In B Vitamin Heaven

I recall vividly the many times I accompanied my father to AMA Conventions while growing up. I am sure now it was a part of his plan to make sure I was brainwashed enough to go to med school and follow along his path.

At one convention, in Atlantic City, when I was about eleven years old, I brought home a treasured back scratcher (an advertising tool from Dome Chemicals, Inc. - ala Merck, Sharp and Dome in the old days) and a shot glass from Phospho-Soda (a shot glass was pretty important in this circle because of all the cocktail parties, especially good for a child with a proctologist father).

I still have these treasures and the memories.

Medicine in those days was less frenzied and treatments were more straight forward and simpler.

And certainly vitamins were not looked upon as voodoo.

Even B12 shots were a regular occurrence and no one needed a blood test to decide if you could get them. Of course now the blood test used - really to get a billable charge and avoid acting outside standards of care - is not the correct test. Remember you can't get hurt by B12 shots but if your provider demands a test it is the INTRACELLULAR B12 that is required.

And - for women only - the correct form and correct dose of injectable B12 can lower your blood pressure.

Pretty much, natural thyroid and B12 were very good at keeping aging folks from dementia, and no one flapped an eyelash over it.

I use B Complex daily and in a food form. I give the same to my animals and we all use organic nutritional yeast which is a fermented product. I think the aroma is to die for, it is such a heavenly aroma that wafts from the container when I open it in the morning at at dinner time.

I certainly am sure I get doses well beyond the fallacy of the RDA, but them I'm more of a follower of nutrition and orthomolecular health models so I'm not frightened that water soluble vitamins will harm me in any way.

I sort of look at the Big Pharma approach to make you think they are on top of things when B3 is added to a dangerous cholesterol drug as odd. Why don't they just admit that the whole cholesterol lowering thing is a scam. B3 does just fine to lower cholesterol on its own, and much less expensively.

I made the mistake of turning on to orthomolecular medicine when I began working in psychiatry as an RN in the early 1970s. With people like Carl C. Pfeiffer, Abrahm Hoffer and Melvin Werbach (all MDs) educating me along the way, added to to great integrated nutrition I had while studying nursing in college, I was way ahead of the pack.

Now after all these years we see maybe the first wave of a turning tide. The AMA reports that B vitamins are good to help older women prevent breast cancer.

Will wonders never cease.....
B vitamins may protect elderly women from cancerDecember 2008

Daily supplementation with B vitamins may reduce the risk of breast cancer and other invasive cancers in women over the age of 65. That’s what a study published in the Journal of the American Medical Association has to say.

Over 5,000 women at a high risk of cardiovascular disease took part in the study, which investigated the effects of a daily supplement of folic acid, vitamin B-6 and vitamin B-12 on cancer risk.

“If the finding [that cancer risk in women over 65 is decreased] is real and substantiated, the results may have public health significance because the incidence rates of cancer are high in elderly persons. The finding is biologically plausible because elderly individuals have increased requirements for these B vitamins,” wrote lead author Shumin Zhang from Brigham and Women’s Hospital and Harvard Medical School.

Folate, vitamin B-6 and vitamin B-12 are thought to play an important role in cancer prevention. This is because the vitamins play an important role in maintaining the integrity of DNA and regulating gene expression, both critical processes in healthy cell function.

Another positive to take from the results is that they appear to support the safety of B vitamins, and particularly folic acid. Since 1998 the U.S. has required mandatory fortification of all grain products with folic acid—the synthetic, bioavailable form of folate—in order to reduce the incidence of neural tube defects—most commonly spina bifida and anencephaly.

Zhang and co-workers looked at the risk of cancer and B-vitamin consumption among the 5,442 participants (average age 62.8) of the Women’s Antioxidant and Folic Acid Cardiovascular Study. The women either had cardiovascular disease or three or more coronary risk factors.

Over the course of 7.3 years, half of the women received a daily supplement of folic acid (2.5 mg), vitamin B-6 (50 mg) and vitamin B-12 (1 mg), while the other half of the women received a placebo. The study began in 1998—the same year as mandatory folic acid fortification was introduced in the U.S.

During the study, 379 cases of invasive cancer were diagnosed—187 in the B-vitamin group and 192 in the placebo group. No differences were seen in the risk of developing total invasive cancer or breast cancer, when the participants were viewed in their entirety. However, in women over the age of 65 the supplementation was associated with significant 25% and 38% reductions in the risk of invasive and breast cancer, respectively.

Journal of the American Medical Association 300(17):2012-2021, 2008