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Wednesday, February 09, 2011

Low Levels of Vitamin D Increase Melanoma Risk

I do quite a lot of reading and repeatedly I see numerous health problems connected with low levels of FAT SOLUBLE VITAMINS and at the same time the push for non-fat food continues.

Again I have to repeat:  If you do not have adequate fat, 2% dairy products at a minimum, you cannot efficiently absorb fat soluble vitamins.

I have been studying nutrition for more than 4 decades and I am pretty sure I know what I am talking about. My best advice is to follow the 2% rule, avoid (especially soy and canola) most vegetable oils except for olive oil and coconut oil, make sure to have some hormone free butter each day, and don't be a fat-a-phobic.  

   Tanning: Vitamins B1 and C can be used to protect your skin, but Suma and DMG can help if skin cancer is an issue for you. 
BYDGOSZCZ, Poland—Results from a recent Polish study found a reduction or absence of vitamin D receptor is linked to progression of melanocytic lesions, and its lack affects survival of melanoma patients, and melanogenesis can attenuate receptor expression (Hum Pathol. 2011 Feb 1). 1,25-dihydroxyvitamin D3 affects proliferation, differentiation and apoptosis, and protects DNA against oxidative damage with a net tumorostatic and anti-carcinogenic effect. It acts through a specific nuclear receptor that is widely distributed through the body. Although a beneficial role of vitamin D in melanoma patients has been suggested, there is lack of information on the changes in the expression pattern of vitamin D receptor during progression of pigmented lesions. Using immunohistochemistry, researchers analyzed the expression of vitamin D receptor in 140 samples obtained form 82 patients, including 25 benign nevi, 70 primary cutaneous melanomas, 35 metastases, 5 re-excisions and 5 normal skin biopsies.
The strongest expression was observed in normal skin that significantly decreased in melanocytic proliferations with the following order of expression: normal skin > melanocytic nevi > melanomas = metastases. The vitamin D receptor expression in skin surrounding nevi and melanoma was also significantly reduced as compared to normal skin. Tumor-infiltrating and lymph node lymphocytes retained high levels of vitamin D receptor. There was negative correlation between tumor progression and vitamin D receptor expression with a remarkable decrease of the immunoreactivity in nuclei of melanoma cells at vertical versus radial growth phases and with metastatic melanomas showing the lowest cytoplasmic receptor staining. Furthermore, lack of the receptor expression in primary melanomas and metastases was related to shorter overall patients' survival. In addition, the receptor expression decreased in melanized melanoma cells in comparison to amelanotic or poorly pigmented cells. The researchers concluded changes in vitamin D receptor expression pattern can serve as important variables for diagnosis, predicting clinical outcome of melanogenesis and/or as a guidance for novel therapy of melanomas based on use of vitamin D or its derivatives. Source: Inside
Selections from Natural Health News
Sep 07, 2008
The FDA also said it is evaluating reports of urinary retention with Eli Lilly's antidepressant Cymbalta, and skin melanoma with Biogen and Elan Corp's multiple sclerosis drug Tysabri. Biogen spokeswoman Shannon Altimari said two cases ...
Aug 04, 2010
As we grow older, our DNA accumulates a considerable amount of unrepairable damage, and under such circumstances even low doses of radiation can trigger the development of skin cancers, including the deadly melanoma. ...
Aug 03, 2010
Martin's colleague Catherine Suter of the Victor Chang Cardiac Research Institute in Sydney is studying whether melanoma patients have epimutations in genes associated with the cancer. It is also conceivable that epimutations could play ...
Mar 25, 2010
Other lifestyle factors like smoking and spending time in the sun have long been implicated in lung cancer and melanoma. Experts say there is now increasing evidence that what people eat and how much they weigh can contribute ...

1 comment:

Vitamins Canada said...

Deficiency in vitamins especially vitamin D can definitely lead to health problems. We should take enough of them, not too much and not too less.